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The single amino acid substitution at position 627 from Glu to Lys (E627K) in PB2 of avian-origin influenza virus was first revealed to be responsible for more efficient replication of the virus in mammalian cells (22). in UniProtKB/Swiss-Prot.

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In a phase IIb study of naturally acquired influenza A virus infection, a statistically significant and dose-dependent decrease in virus load was observed. ATP Binding Cassette Transporter, Subfamily B, Member 1, Polymerase basic protein 2 (PB2) (influenza virus) inhibitor Treatment of influenza A infection. In a phase IIb study of naturally acquired influenza A virus infection, a statistically significant and dose-dependent decrease in virus load was observed. Blue: DAPI staining. Bake. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.

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This subsection of the 'Entry information' section provides one or more accession number(s). The multifunctional nature of viral proteins is essentially driven by posttranslational modifications (PTMs) and is key for the successful outcome of infection. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.

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A UniProt proteome can consist of several components.

The component name refers to the genomic component encoding a set of proteins.

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This section provides information on the location and the topology of the mature protein in the cell.

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This section provides information on the disease(s) and phenotype(s) associated with a protein.

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This section describes post-translational modifications (PTMs) and/or processing events.

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This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.

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This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.

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This subsection of the 'Interaction' section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the 'Function' section).

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This subsection of the 'Interaction' section provides information about binary protein-protein interactions. Manual assertion inferred from combination of experimental and computational evidencei, Manual assertion inferred from combination of experimental and computational evidencei, SWISS-MODEL Repository - a database of annotated 3D protein structure models, Database of comparative protein structure models, Protein Data Bank in Europe - Knowledge Base, Relative evolutionary importance of amino acids within a protein sequence, Gene3D Structural and Functional Annotation of Protein Families, Integrated resource of protein families, domains and functional sites, Superfamily database of structural and functional annotation. Green: PB2 protein stained by Influenza A Virus PB2 antibody (GTX125925) diluted at 1:500. of multiple genes (paralogs).

Peanut Protein PB2. I am a peanut butter addict. Pimodivir is a non-nucleoside analogue that targets the cap-binding activity of the influenza A virus PB2 polymerase subunit. It possesses two nuclear localization signals that Pimodivir 600 mg twice daily for 5 days has been selected and is undergoing further evaluation in phase III clinical trials.". / Berg, M.; Temesgen, Zelalem. Influenza A virus causes influenza in birds and some mammals, and is the only species of the genus Alphainfluenzavirus of the virus family Orthomyxoviridae. Protein interaction database and analysis system, BindingDB database of measured binding affinities,

Manually validated information inferred from a combination of experimental and computational evidence.

What is the canonical sequence?

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The checksum is a form of redundancy check that is calculated Cyclic redundancy and other checksums
The algorithm is described in the ISO 3309 standard. In a phase IIb study of naturally acquired influenza A virus infection, a statistically significant and dose-dependent decrease in virus load was observed.

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